killing of virus-infected or malignant cells (requires CD8+ cytotoxic T cells).delayed-type hypersensitivity responses (require CD4+ T cells).cell-mediated immune responses, which require CD4+ and/or CD8+ T cells.antibody formation that requires CD4+ helper T cells.Therefore they are unable to mount many types of adaptive immune responses, including: Because they lack a thymus, nude mice cannot generate mature T lymphocytes. Grist at Ruchill Hospital's Brownlee virology laboratory in Glasgow. Nude mice were first discovered in 1962 by Dr. Then in 2000, the gene responsible for the mutation was identified as a member of the Fox gene family and the nomenclature was updated to Foxn1nu. Originally they were described as nu and this was updated to Hfh11nu when the mutated gene was identified as a mutation in the HNF-3/forkhead homolog 11 gene. The nomenclature for the nude mouse has changed several times since their discovery. The genetic basis of the nude mouse mutation is a disruption of the FOXN1 gene. These xenografts are commonly used in research to test new methods of imaging and treating tumors. The nude mouse is valuable to research because it can receive many different types of tissue and tumor grafts, as it mounts no rejection response. The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the 'nude' nickname. I suggest you be prepared.Lab mouse strain lacking immunity and fur A nude mouseĪ nude mouse is a laboratory mouse from a strain with a genetic mutation that causes a deteriorated or absent thymus, resulting in an inhibited immune system due to a greatly reduced number of T cells. I haven't felt that uncomfortable at the theater since the My Own Private Idaho fiasco. You'll most likely watch it through squinted eyes. At least warn them that sometimes the person they least suspect could be the one to be most wary of.Ī quick word of warning to all you guys: there is one particular scene where what we perceive is happening will absolutely make you squirm in your seat. Hard Candy refuses to send you prancing home with a smile on your face or a song in your heart, but if nothing else it serves as a strong warning that you should probably pay close attention to who your kids are communicating with online. That subplot is dropped faster than Britney Spears' baby, never to be heard from again. The only purpose it serves is to deliver a little faux drama. The worst example being a scene involving Sandra Oh's neighbor character. After a while it becomes too obvious that certain scenes and lines of dialogue are, like most songs on recent Rolling Stones albums, inserted for no other reason than to serve as filler. At 103 minutes this is just way too long. I did feel she was a bit too precocious and world-wise at times, but she still does a great job showcasing a wide range of emotions of this potential young victim.ĭespite the interesting concept of the two-person show, it clearly has its limitations. Page who turns in an impressive performance. That's all I'm revealing regarding the story, but I do have to give kudos to Ms. This all starts quietly enough, but once they get to his house gears are shifted and everything goes haywire. After all, he obviously has the most innocent of intentions! Why else would he reassure her that he's aware of the legal boundaries? She's puddy in his hands. He can't be bad, right? 'You look older than you are, and you certainly act older than you are,' he tells Hayley, perfectly manipulating her young, fragile emotions. Most young girls are smart enough to do wind sprints the moment they see a dirty, unkempt man who looks to be carrying more diseases than Paris Hilton.īut Wilson is a good-looking, successful photographer. I don't know if Wilson should take this as a compliment, but he's very convincing as a dangerously innocent-seeming pedophile. Given this challenge, the two thespians more than hold their own. There are a total of five people in the movie, and only Wilson and Page are given more than five minutes of screen time. Best of luck!' Granted, I'm paraphrasing, but this is no exaggeration. What the filmmakers have done is said, 'Hey, Patrick Wilson! Ellen Page! We're placing the two of you in a restricted space and putting the entire movie on your shoulders. I don't need a rash of emails reminding me of my chauvinism. Let's make that a one-man, one-girl show. Though it is not one to recommend for 'Family Night,' Hard Candy offers an intriguing one-time viewing thanks to the effectiveness of its two-man show approach.

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